Type 2 diabetes is an insidious disease that causes stroke, heart attack, vascular disease and blood pathology. Metformin-Teva is synthesized based on natural materials. That is why the drug successfully fights this disease.

Release form, composition and packaging

Metformin-Teva tablets are available in various dosages - 500, 850 and 1000 mg of metformin in one.

In addition, the preparation contains auxiliary substances:

  • copovidone - a binding component for the formation of the desired form of the substance;
  • polyvidone - has a hydrating (saturates with water) effect, helps to remove toxins, activates the kidneys;
  • microcrystalline cellulose - normalizes blood sugar, removes toxins, improves the functioning of the kidneys and gastrointestinal tract;
  • Aerosil - a sorbent that allows you to effectively remove protein compounds, which contributes to the effective cleansing of the body;
  • magnesium stearate - filler;
  • Opadry II is a film coating component.

A cardboard package contains either three or six blisters of ten tablets in one. The shape can be round (500 mg) or elongated (850 and 1000 mg).

Pharmacological action, pharmacodynamics and pharmacokinetics

The effect of the drug is determined by the pharmacological effect of the main active substance - biguanide. The pure form of the substance (guanidine), discovered initially, was highly toxic to liver tissue.But its synthesized form is included in the list of essential medicines by the World Health Organization.

The action of biguanide causes:

  • improvement of natural metabolic processes;
  • maintaining glycemia (blood sugar) at a normal level;
  • improving glucose output from adipose and muscle tissues;
  • increased insulin sensitivity;
  • resorption of blood clots.

"Metformin-Teva" is a hypoglycemic agent, however, at the time of a low or normal level of insulin, its activity is leveled.

The pharmacodynamics of the drug is to slow down the production of glucose in the liver. Moreover, Metformin-Teva does not cause hypoglycemia. During the course of the drug, lactic acidosis does not occur (plasma poisoning with lactic acid), pancreatic function is not suppressed. In addition, the drug lowers cholesterol, smoothes the activity of insulin in the production of fatty tissues, which helps to normalize weight.
"Metformin-Teva" also prevents vascular damage, thereby positively affecting the cardiovascular system as a whole.

The drug has a slow pharmacokinetics due to the low ability to bind to blood proteins. Plasma concentration reaches a maximum after 2-3 hours from the time of administration, and the equilibrium concentration - no more than two days later. "Metformin-Teva" is removed from the body through the kidneys unchanged. Therefore, in people with a disruption in the functioning of this body, the accumulation of metformin in saliva and liver is possible. The half-life is no more than 12 hours.

What is the drug prescribed

Metformin-Teva tablets are prescribed for patients who suffer from type 2 diabetes mellitus without ketoacid type disorders. The drug is used if there is no effect of a change in diet to a more dietary one in people with a tendency to obesity. It is also possible to combine the drug with insulin for patients with loss of sensitivity to insulin.

Instructions for use Metformin-Teva 500 mg, 850 mg, 1000 mg

The daily dose of the drug should be prescribed by a doctor. The basis for the decision will be a blood test of the patient. The instructions for use indicate that the drug must be taken either with food, or immediately after it. The tablet must be swallowed whole without chewing, washed down with the required amount of water.
The initial dosage for monotherapy or combination with other anti-diabetes drugs is 1000 mg per day. It is possible to divide the dose into several doses to normalize the digestive tract and addiction. After 10-14 days, a moderate increase in dosage to 2000 mg per day is possible. This is a maintenance dosage recommended for most patients.

It is maximum permissible to take no more than 3 g of the drug per day.

For combination therapy with insulin, it is recommended to take Metformin-Teva in a dosage of 500 or 850 mg. This is convenient for dividing into 2-3 doses. The amount of insulin is selected based on a blood test.

The duration of treatment is determined by the therapist based on individual indicators.

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Drug interaction

The effect of the drug "Metformin-Teva" has a decrease in the action of a number of substances:

  • diuretics;
  • steroid hormones produced by the adrenal cortex (e.g., glucagon);
  • phenothiazines;
  • thyroid hormones;
  • estrogen (including as part of oral contraceptives).

However, nifedipine while taking metformin is able to increase the maximum concentration of the latter in plasma by 20%. Furosemide also has the same effect. No long-term exposure studies have been conducted.

A significant increase in the concentration in the body (up to 60%) of metformin is caused by simultaneous therapy with drugs whose secretion occurs through the renal tubule. And taking cimetidine slows down the withdrawal of metformin, which can provoke lactic acidosis.

During pregnancy and lactation

Treatment with the Metformin-Teva medication during gestation is possible if the intended therapeutic effect is significantly higher than the threat. In general, studies involving pregnant women taking the drug have not been conducted. Admission during lactation is strictly prohibited.

Alcohol compatibility

Taking the Metformin-Teva medication is not compatible with alcohol. As a result of taking any amount of it, there is a danger of a sharp lactic acidosis, the consequences of which can lead to unpredictable results, even death.

Contraindications, side effects and overdose

The drug has a number of contraindications:

  • intolerance to any of the components of the drug;
  • impaired liver or kidney function, insufficient creatinine;
  • a state of low blood oxygen;
  • any types of infectious diseases;
  • dehydration of the body;
  • surgery and significant injuries;
  • chronic alcoholism;
  • low daily calorie intake (less than a thousand);
  • shift of acid-base balance in the direction of increasing acidity;
  • ketoacidosis;
  • pregnancy or lactation.

It is necessary to refuse to take the drug 48 hours before and after any type of study using a contrast medium.

Side effects are possible with varying degrees of probability.

  1. From the gastrointestinal tract. Nausea or vomiting, increased gas formation, diarrhea, a sharp decrease in weight up to anorexia (the result depends on the initial weight of the patient), pain in the abdominal cavity of a different nature (the intensity can be leveled if you organize the reception together with food), the taste of iron.
  2. From the hemopoietic system. Malignant anemia associated with a deficiency (or poor absorption) of vitamin B12.
  3. From the metabolic processes of the body. A pathological decrease in plasma glucose.
  4. From the dermis. Rash or dermatitis.

An overdose can be caused by a violation of the amount of the drug used. The consequence of this may be aerobic (type B) acidosis.

Analogues of the drug

"Metformin-Teva" has many analogues that have certain advantages and disadvantages.

Metformin MV-Teva

The drug is available in a dosage of 500 mg, 60 pieces per pack. It has a prolonged effect in relation to the usual drug. The cost of the course does not have noticeable differences.

Glucophage

The drug contains metformin in a dosage similar to the Metformin-Teva medication. However, the effect of Glucophage is smoother due to the absence of a number of excipients in the tablet. Due to this, in addition to the opportunity to reduce the dosage (as agreed with the therapist), the drug has a significantly lower number of side effects from the gastrointestinal tract.

Bagomet, Glycomet, Dianormet, Diaformin

Absolute analogues of the drug "Metformin-Teva" in concentration and composition of the main active substance. However, there are differences in the list of excipients that do not have a significant effect on pharmacokinetics. Therefore, in addition to a slight difference in cost, there are no differences with Metformin-Teva.

Combogliz Prolong

A drug that combines two antidiabetic drugs with a different mechanism of action. Metfomin is a biguanide that suppresses the amount of bound insulin and increases its output from the body. Saxagliptin is a substance that suppresses specific enzymes and prolongs the action of hormones that stimulate the natural production of insulin. Complementing each other, the active substances provide a modified release. This means that the drug interacts under certain conditions. Therefore, its use is possible without complications and with a minimum number of contraindications. Undoubtedly, “Combogliz Prolong” is more effective.However, it is the next generation of drugs designed to treat type 2 diabetes.

"Metformin-Teva" is an effective drug for the treatment of type 2 diabetes. Its cost is quite acceptable, and the effective action has been studied and proven by numerous studies.

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